Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin
deltonin
CAS: 55659-75-1
Molecular Formula: C45H72O17
Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin - Names and Identifiers
Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin - Physico-chemical Properties
| Molecular Formula | C45H72O17 |
| Molar Mass | 885.04 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 298-300 °C (decomp) |
| Solubility | Soluble in methanol |
| Appearance | Powder |
| pKa | 12?+-.0.70(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC 50 s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells. Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA‑MB‑231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA‑MB‑231 cells. |
| In vivo study | Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice. |
Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin - Reference
| Reference Show more | 1. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150 |
Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin - Reference Information
| overview | turmeric, known as DioscoreazingiberensisC.H.Wright, is a plant of the genus Dioscorea of the Dioscoreaceae family and is a unique wild plant resource in China. Diosgenin (Deltonin) is one of the various saponins contained in Dioscorea zingiberensis. Dioscin triangularis has a variety of pharmacological activities in the fight against cardiovascular diseases, such as: protecting vascular endothelial cells, lowering blood lipids, preventing and treating thrombosis, improving coronary blood supply, and preventing and treating myocardial infarction. |
| biological activity | Deltonin is a steroidal saponin obtained from Dioscorea zingiberensis, which can inhibit the activation of ERK1/2 and AKT and has anti-tumor activity. |
| target | ERK1 ERK2 Akt Human Endogenous Metabolite |
| in vitro study | Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC 50 s of 1.3, 1.29, 2.11 and 1.22 μ m. Deltonin also uses G2-M phase arrest and induces apoptosis in C26 cells. Deltonin (0-5μ m) decreases the phosphorylation of akt and erk1/2 levels in mdab-mb-231 cells. Deltonin (0.5-8μ m) also dose-dependently inhibits the proliferation, and uses apoptosis with ROS production in-mabmb 231 cells. |
| in vivo study | Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and problems a 50-day survival rate of 60% and 50%, respectively, in ice. Deltonin also inhibits angiogenesis in ice. |
Last Update：2024-04-09 21:31:58
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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